← Back to Search

2006 Mercedes-Benz E-Class E350

All Mercedes-Benz E-Class W211 trims (2003–2009) → All Mercedes-Benz E-Class generations →
2006 Mercedes-Benz E-Class – front Unverified
Photo: Mercedes-Benz W211 FL E 280 Iridium Silver Metallic (1) by Damian B Oh, CC BY-SA 4.0, via Wikimedia Commons
Photos show the W211 (W211, 2003–2009); trim, color, and model year may differ.
All photo credits
  1. Photo: Mercedes-Benz W211 FL E 280 Iridium Silver Metallic (1) by Damian B Oh, CC BY-SA 4.0, via Wikimedia Commons
  2. Photo: MERCEDES-BENZ E-CLASS (W211) China (5) by Dinkun Chen, CC BY-SA 4.0, via Wikimedia Commons
  3. Photo: Mercedes Benz E320 Side View (cropped) by Arewell, CC BY-SA 4.0, via Wikimedia Commons
  4. Photo: Mercedes-Benz E 500 Elegance (W 211) – Heckansicht, 13. Mai 2011, Velbert by M 93, CC BY-SA 3.0 de, via Wikimedia Commons
  5. Photo: Mb e500 023 by Dr. Thomas Bastian, CC BY-SA 3.0, via Wikimedia Commons

The 2006 Mercedes-Benz E-Class E350 is a 268-hp 3.5-liter V6 with an automatic 7-spd and rear-wheel drive. It is rated at 20 mpg combined.

It makes 268 horsepower at 6,000 rpm and 258 lb-ft of torque at 2400-5000 rpm. EPA fuel-economy estimates are 17 mpg city and 25 mpg highway (20 mpg combined).

The E-Class measures 189.7 inches long on a 112.4-inch wheelbase.

Spec Value
Vehicle
Body TypeSedan
PowertrainGas
Engine
Engine Type3.5L V6 (M272)
Displacement3.5 L
Horsepower268 hp @ 6,000 rpm
Torque258 lb-ft @ 2400-5000 rpm
Drivetrain
Drive TypeRWD
Transmission
TransmissionAutomatic 7-spd
Fuel Economy
City17 MPG
Highway25 MPG
Combined20 MPG
Recommended FuelPremium Gasoline
Dimensions & Weight
Length189.7 in
Width71.7 in
Height57 in
Wheelbase112.4 in

Similar cars

Rivals to the 2006 Mercedes-Benz E-Class E350 with similar size, power and price from around the same years.

2006 Infiniti G35 Unverified

2006 Infiniti G35

Sedan
280 hp · $31,450
Compare
2007 Toyota Camry

2007 Toyota Camry

LE V6
268 hp · $23,540
Compare
2007 Nissan Altima Unverified

2007 Nissan Altima

3.5 SE 6MT
270 hp · $24,000
Compare
2005 BMW 5 Series Unverified

2005 BMW 5 Series

530i
255 hp · $45,400
Compare
2005 Acura TL

2005 Acura TL

Base MT
270 hp · $33,100
Compare
2007 Lexus ES

2007 Lexus ES

350
272 hp · $33,470
Compare

Safety & Recalls

NCAP safety ratings

Overall Not rated
Frontal crash Not rated
Frontal – driver ★★★★★
Frontal – passenger ★★★★★
Side crash Not rated
Rollover Not rated
Tested variant: 2006 Mercedes-Benz E-Class 4-DR. w/SAB

Recalls

No recalls on file with NHTSA for the 2006 Mercedes-Benz E-CLASS.

538 owner complaints to NHTSA for the 2006 Mercedes-Benz E-CLASS

Owner Complaints

538 owner complaints filed with NHTSA for the 2006 Mercedes-Benz E-CLASS (18 mention a crash, 9 a fire, 15 an injury). See all on nhtsa.gov

Most-cited areas
Fuel/Propulsion System184
Fuel System120
Gasoline118
Service Brakes75
Engine51
Power Train39
A complaint can cite more than one area.
Most recent complaints
Oct 15, 2026 · Service Brakes, Hydraulic
“The contact owns a 2006 Mercedes-Benz E350. While driving at 30 MPH, a "Reduced Braking Power" warning message was displayed on the instrument panel followed by an audible alarm. The brake pedal…”
Sep 23, 2026 · Service Brakes, Hydraulic, Electrical System
“The contact owns a 2006 Mercedes-Benz E-350. The contact stated that the sensotronic brake control warning was illuminated. The contact researched and found information about warranty coverage for…”
Mar 11, 2026 · Fuel System, Gasoline
“The contact owns a 2006 Mercedes-Benz E500. The contact stated that while driving at an undisclosed speed, the contact became aware of a fuel leak, and the check engine warning light was illuminated…”
Dec 3, 2025 · Service Brakes, Forward Collision Avoidance
“Mercedes Benz issued a recall and extended a warranty on its 2003-2005 E Class SBC braking systems (recall # 2005110001) and extended the warranty to 25 years; the 2006 E Class models have the exact…”
Oct 23, 2025 · Service Brakes, Hydraulic
“The contact called on behalf of the owner of a 2006 Mercedes-Benz E350. The contact stated that while his mother was driving at an undisclosed speed and approaching a traffic light, the brake pedal…”

Complaints are unverified reports submitted to NHTSA by owners. They cover the whole model year, not a specific trim, and a count alone doesn't show how common a problem is.

Source: US National Highway Traffic Safety Administration (nhtsa.gov), matched as 2006 MERCEDES-BENZ E-CLASS. US-market vehicles only; data cached for up to 7 days.

← Back to Search