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2006 Mercedes-Benz E-Class Wagon E350 4MATIC

All Mercedes-Benz E-Class Wagon S211 trims (2004–2009) → All Mercedes-Benz E-Class Wagon generations →
2006 Mercedes-Benz E-Class Wagon – front Unverified
Photo: 2004 Mercedes-Benz E500 4Matic Wagon in Brilliant Silver Metallic, Front Left, 08-13-2023 by Elise240SX, CC BY-SA 4.0, via Wikimedia Commons
Photos show the S211 (S211, 2004–2009); trim, color, and model year may differ.
All photo credits
  1. Photo: 2004 Mercedes-Benz E500 4Matic Wagon in Brilliant Silver Metallic, Front Left, 08-13-2023 by Elise240SX, CC BY-SA 4.0, via Wikimedia Commons
  2. Photo: Mercedes E-Klasse T-Modell 20090308 front by M 93, Public domain, via Wikimedia Commons
  3. Photo: E 270 CDI T 2 by Matti Blume, MB-one, CC BY-SA 3.0, via Wikimedia Commons
  4. Photo: 2004 Mercedes-Benz E500 4Matic Wagon in Brilliant Silver Metallic, Rear Left, 08-13-2023 by Elise240SX, CC BY-SA 4.0, via Wikimedia Commons
  5. Photo: Mercedes E-Klasse T-Modell 20090308 rear by M 93, Public domain, via Wikimedia Commons

The 2006 Mercedes-Benz E-Class Wagon E350 4MATIC is a 268-hp 3.5-liter V6 wagon with an automatic 5-spd and all-wheel drive. It is rated at 18 mpg combined.

It makes 268 horsepower at 6,000 rpm and 258 lb-ft of torque at 2400-5000 rpm. EPA fuel-economy estimates are 16 mpg city and 22 mpg highway (18 mpg combined).

The E-Class Wagon measures 190.9 inches long on a 112.4-inch wheelbase.

Spec Value
Vehicle
Body TypeWagon
PowertrainGas
Engine
Engine Type3.5L V6 (M272)
Displacement3.5 L
Horsepower268 hp @ 6,000 rpm
Torque258 lb-ft @ 2400-5000 rpm
Drivetrain
Drive TypeAWD
Transmission
TransmissionAutomatic 5-spd
Fuel Economy
City16 MPG
Highway22 MPG
Combined18 MPG
Recommended FuelPremium Gasoline
Dimensions & Weight
Length190.9 in
Width71.7 in
Height58.9 in
Wheelbase112.4 in

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Safety & Recalls

NCAP safety ratings

Overall Not rated
Frontal crash Not rated
Frontal – driver ★★★★★
Frontal – passenger ★★★★★
Side crash Not rated
Rollover Not rated
Tested variant: 2006 Mercedes-Benz E-Class 4-DR. w/SAB

Recalls

No recalls on file with NHTSA for the 2006 Mercedes-Benz E-CLASS.

538 owner complaints to NHTSA for the 2006 Mercedes-Benz E-CLASS

Owner Complaints

538 owner complaints filed with NHTSA for the 2006 Mercedes-Benz E-CLASS (18 mention a crash, 9 a fire, 15 an injury). See all on nhtsa.gov

Most-cited areas
Fuel/Propulsion System184
Fuel System120
Gasoline118
Service Brakes75
Engine51
Power Train39
A complaint can cite more than one area.
Most recent complaints
Oct 15, 2026 · Service Brakes, Hydraulic
“The contact owns a 2006 Mercedes-Benz E350. While driving at 30 MPH, a "Reduced Braking Power" warning message was displayed on the instrument panel followed by an audible alarm. The brake pedal…”
Sep 23, 2026 · Service Brakes, Hydraulic, Electrical System
“The contact owns a 2006 Mercedes-Benz E-350. The contact stated that the sensotronic brake control warning was illuminated. The contact researched and found information about warranty coverage for…”
Mar 11, 2026 · Fuel System, Gasoline
“The contact owns a 2006 Mercedes-Benz E500. The contact stated that while driving at an undisclosed speed, the contact became aware of a fuel leak, and the check engine warning light was illuminated…”
Dec 3, 2025 · Service Brakes, Forward Collision Avoidance
“Mercedes Benz issued a recall and extended a warranty on its 2003-2005 E Class SBC braking systems (recall # 2005110001) and extended the warranty to 25 years; the 2006 E Class models have the exact…”
Oct 23, 2025 · Service Brakes, Hydraulic
“The contact called on behalf of the owner of a 2006 Mercedes-Benz E350. The contact stated that while his mother was driving at an undisclosed speed and approaching a traffic light, the brake pedal…”

Complaints are unverified reports submitted to NHTSA by owners. They cover the whole model year, not a specific trim, and a count alone doesn't show how common a problem is.

Source: US National Highway Traffic Safety Administration (nhtsa.gov), matched as 2006 MERCEDES-BENZ E-CLASS. US-market vehicles only; data cached for up to 7 days.

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