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2021 Mercedes-Benz E-Class E 450 4MATIC

All Mercedes-Benz E-Class W213 trims (2017–2023) → All Mercedes-Benz E-Class generations →
2021 Mercedes-Benz E-Class – front Unverified
Photo: Mercedes-Benz W213 FL E 350 4MATIC AMG Line Obsidian Black Metallic (22) by Damian B Oh, CC BY-SA 4.0, via Wikimedia Commons
Photos show the W213/C238/A238 (facelift) (W213, 2017–2023); trim, color, and model year may differ.
All photo credits
  1. Photo: Mercedes-Benz W213 FL E 350 4MATIC AMG Line Obsidian Black Metallic (22) by Damian B Oh, CC BY-SA 4.0, via Wikimedia Commons
  2. Photo: Mercedes-Benz W213 FL E 350 4MATIC AMG Line Obsidian Black Metallic (21) by Damian B Oh, CC BY-SA 4.0, via Wikimedia Commons
  3. Photo: 2022 Mercedes E200 AMG LINE MHEV Auto by Calreyn88, CC BY-SA 4.0, via Wikimedia Commons
  4. Photo: Mercedes-Benz E350eL (rear), November 4, 2024 by メイド理世, CC BY-SA 4.0, via Wikimedia Commons
  5. Photo: Mercedes-Benz E 200 Sports (W213) interior by Tokumeigakarinoaoshima, CC BY-SA 4.0, via Wikimedia Commons

The 2021 Mercedes-Benz E-Class E 450 4MATIC is a 362-hp 3.0-liter turbocharged inline-6 with a 9g-tronic 9-speed automatic and all-wheel drive. It starts at $62,000 MSRP and is rated at 26 mpg combined.

It makes 362 horsepower at 5,500 rpm and 369 lb-ft of torque, spinning to a 6,800 rpm redline. EPA fuel-economy estimates are 23 mpg city and 30 mpg highway (26 mpg combined).

The E-Class measures 194.3 inches long on a 115.7-inch wheelbase and has a curb weight of 4,222 lb.

Spec Value
Vehicle
Body TypeSedan
PowertrainGas
Price
MSRP$62,000
MSRP with Destination$63,050
Destination Charge$1,050
Engine
Engine Type3.0L Inline-6 Turbo with EQ Boost (48V ISG)
Displacement3 L
Horsepower362 hp @ 5,500 rpm
Torque369 lb-ft @ 1600-4500 rpm (+184 lb-ft EQ Boost) rpm
Redline6,800 rpm
ValvetrainDOHC, 4-valves per cylinder
Bore and Stroke83.0 x 92.0
Compression Ratio10.5:1
Drivetrain
Drive Type4MATIC All-Wheel Drive
Transmission
Transmission9G-TRONIC 9-Speed Automatic
1st Gear5.35 (36 mph **)
2nd Gear3.24 (59 mph **)
3rd Gear2.25 (85 mph **)
4th Gear1.64 (117 mph **)
5th Gear1.21 (158 mph **)
6th Gear1 (191 mph **)
7th Gear0.87 (220 mph **)
8th Gear0.72 (266 mph **)
9th Gear0.6 (319 mph **)
Reverse4.79
Final Drive2.82
Fuel Economy
City23 MPG
Highway30 MPG
Combined26 MPG
Tank Capacity21.1 gal
Brakes
Front Brake Disc14.2"
Rear Brake Disc14.2"
Tires & Wheels
Wheels Front8 x 18 (Cast)
Wheels Rear8 x 18 (Cast)
Tires Front245/45 R18
Tires Rear245/45 R18
Dimensions & Weight
Length194.3 in
Width81.3 in
Height57.8 in
Wheelbase115.7 in
Front Track62.9 in
Rear Track63 in
Ground Clearance3.8 in
Cargo Volume13.1 ft³
Curb Weight4,222 lbs
Interior
Headroom Front37.3 in
Headroom Rear37.6 in
Legroom Front41.7 in
Legroom Rear36.1 in
Shoulder Room Front57.8 in
Shoulder Room Rear57.1 in
** Theoretical max speed per gear at redline

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Safety & Recalls

NCAP safety ratings

Overall ★★★★★
Frontal crash ★★★★★
Side crash ★★★★★
Rollover ★★★★★ (9.7 % risk)
Tested variant: 2021 Mercedes-Benz E-Class 4 DR 4WD
Other tested variants (5)
  • 2021 Mercedes-Benz E-Class 4 DR RWD: 5 ★ overall
  • 2021 Mercedes-Benz E-Class 2DR 4WD: overall not rated
  • 2021 Mercedes-Benz E-Class SW 4WD: 5 ★ overall
  • 2021 Mercedes-Benz E-Class 2DR RWD: overall not rated
  • 2021 Mercedes-Benz E-Class SW RWD: 5 ★ overall

Recalls

No recalls on file with NHTSA for the 2021 Mercedes-Benz E-CLASS.

20 owner complaints to NHTSA for the 2021 Mercedes-Benz E-CLASS

Owner Complaints

20 owner complaints filed with NHTSA for the 2021 Mercedes-Benz E-CLASS (1 a fire). See all on nhtsa.gov

Most-cited areas
Electrical System7
Engine6
Back Over Prevention3
Power Train3
Fuel/Propulsion System2
Unknown Or Other2
A complaint can cite more than one area.
Most recent complaints
Aug 8, 2026 · Power Train
“Engine misfires, lower engine power, and a lit check engine/Malfunction Indicator Lamp. Mercedes-Benz issued an Emission Service Campaign (No. 2021070006, internal code 21P1590208) to replace…”
May 8, 2026 · Electrical System, Fuel/Propulsion System
“Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP)…”
Jan 4, 2026 · Power Train
“With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .”
Dec 27, 2025 · Engine
“Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the…”
Jul 14, 2025 · Engine
“My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to…”

Complaints are unverified reports submitted to NHTSA by owners. They cover the whole model year, not a specific trim, and a count alone doesn't show how common a problem is.

Source: US National Highway Traffic Safety Administration (nhtsa.gov), matched as 2021 MERCEDES-BENZ E-CLASS. US-market vehicles only; data cached for up to 7 days.

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